CJC-1295 (No DAC) also commonly known as Modified GRF (1-29) is a synthetic tetrasubstituted 29-amino acid peptide analog of naturally occurring Growth Hormone-Releasing Hormone (GHRH). Formulated as a high-purity 5mg lyophilized dose, CJC-1295 (No DAC) is widely utilized in laboratory research examining pulsatile growth hormone secretagogue activity, anterior pituitary cellular signaling, and insulin-like growth factor (IGF-1) cascade activation.
Unlike CJC-1295 with DAC (Drug Affinity Complex), the No DAC variant does not contain the maleimidopropionic acid linker, resulting in a shorter, physiological half-life (~30 minutes) that allows researchers to mimic organic, episodic pituitary GH release.
Key Product Specifications
| Specification | Details |
| Product Name | CJC-1295 (No DAC) / Modified GRF (1-29) |
| Quantity | 5mg per vial |
| Purity | $\ge 98\%$ (RP-HPLC verified) |
| Form | Sterile, lyophilized white powder |
| CAS Number | 863288-34-0 |
| Molecular Formula | $\text{C}_{152}\text{H}_{252}\text{N}_{44}\text{O}_{42}$ |
| Molecular Weight | 3367.97 g/mol |
| Sequence | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 |
Product Highlights & Scientific Context
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Pulsatile Secretion Profile: Lacks the albumin-binding DAC complex, enabling exact temporal control over GHRH receptor stimulation without continuous baseline elevation.
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Tetrasubstituted Stability: Features four specific amino acid substitutions ($\text{D-Ala}^2$, $\text{Gln}^8$, $\text{Ala}^{15}$, and $\text{Leu}^{27}$) that significantly increase resistance to cleavage by Dipeptidyl Peptidase-4 (DPP-IV) compared to natural GHRH (1-29).
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Synergistic Model Target: Frequently paired in dual-secretagogue research models with Growth Hormone Releasing Peptides (GHRPs like Ipamorelin or GHRP-2) to investigate synergistic GH secretion dynamics.
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Lyophilized Quality: Sealed under sterile nitrogen in borosilicate glass vials to maintain secondary structure and long-term chemical integrity.
Storage & Handling Guidelines
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Lyophilized Powder: Store at -20°C or -80°C protected from light and moisture for up to 2 years. Short-term storage (under 30 days) at 2–8°C.
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Reconstituted Solution: Once reconstituted with Bacteriostatic Water or sterile saline, store at 2°C – 8°C and use within 30 days. Avoid repeated freeze-thaw cycles.
Disclaimer & Research Notice:
This product is sold strictly for laboratory research and analytical purposes only. It is not intended for human consumption, medical diagnosis, therapeutic treatment, or cosmetic applications. All products should be handled by qualified scientific personnel using proper laboratory safety protocols.
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