MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino acid mitochondrial-derived peptide (MDP). Formulated at a high-purity 10mg lyophilized dose, MOTS-c acts as a endocrine-like signaling factor that targets skeletal muscle and liver tissue to regulate metabolic homeostasis, cellular energy balance, glucose utilization, and exercise-mimetic pathways.
Translocating to the nucleus during metabolic stress, MOTS-c directly regulates nuclear gene expression, making it a primary focus in longevity, metabolic syndrome, and cellular senescence research.
Key Product Specifications
| Specification | Details |
| Product Name | MOTS-c (Mitochondrial Derived Peptide) |
| Quantity | 10mg per vial |
| Purity | $\ge 98\%$ (RP-HPLC & Mass Spectrometry verified) |
| Form | Sterile, lyophilized white powder |
| CAS Number | 1627580-64-6 |
| Molecular Formula | $\text{C}_{101}\text{H}_{152}\text{N}_{28}\text{O}_{22}\text{S}_2$ |
| Molecular Weight | $2174.6\text{ g/mol}$ |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
Product Highlights & Scientific Context
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AMPK Pathway Activation: Activates AMP-activated protein kinase (AMPK) independent of the classical upstream kinase pathways, stimulating intracellular glucose uptake and fatty acid oxidation.
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Metabolic Flexibility & Exercise Mimetic: Evaluated in preclinical models for its ability to enhance insulin sensitivity, prevent diet-induced obesity, and improve physical capacity without altering caloric intake.
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Mitochondrial-to-Nuclear Signaling: Uniquely translocates to the nucleus upon cellular metabolic stress to interact with stress-responsive transcription factors (e.g., Nrf2) and restore metabolic equilibrium.
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Longevity & Anti-Senescence Focus: Investigated for its role in counteracting age-dependent metabolic decline and maintaining skeletal muscle cellular integrity.
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Aseptic Lyophilization: Freeze-dried under nitrogen flush in borosilicate glass vials to ensure optimal structural preservation and long-term shelf life.
Storage & Handling Guidelines
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Lyophilized Powder: Store at -20°C or -80°C protected from light and moisture for up to 2 years. Short-term storage (under 30 days) at 2–8°C.
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Reconstituted Solution: Once reconstituted with Bacteriostatic Water or sterile saline, store strictly at 2°C – 8°C and use within 28–30 days. Avoid repeated freeze-thaw cycles.
Disclaimer & Research Notice:
This product is sold strictly for laboratory research and analytical purposes only. It is not intended for human consumption, medical diagnosis, therapeutic treatment, or cosmetic applications. All products should be handled by qualified scientific personnel using proper laboratory safety protocols.
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