TB-500 is a synthetic peptide containing the primary active fragment ($\text{LKKTETQ}$) of naturally occurring Thymosin Beta-4 ($\text{T}\beta_4$). Formulated as a high-purity 10mg lyophilized dose, TB-500 is an extensively studied peptide in cellular repair and regenerative biology. It is primarily investigated for its ability to regulate G-actin polymerization, promote cellular migration, stimulate angiogenesis (new blood vessel formation), and reduce fibrous tissue deposition in damaged muscle, tendon, and ligament tissues.
Key Product Specifications
| Specification | Details |
| Product Name | TB-500 (Thymosin Beta-4 Active Fragment) |
| Quantity | 10mg per vial |
| Purity | $\ge 98\%$ (RP-HPLC & Mass Spectrometry verified) |
| Form | Sterile, lyophilized white powder |
| CAS Number | 77591-33-4 |
| Molecular Formula | $\text{C}_{212}\text{H}_{350}\text{N}_{56}\text{O}_{78}\text{S}$ |
| Molecular Weight | $4963.5\text{ g/mol}$ |
| Sequence | Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser |
Product Highlights & Scientific Context
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Actin Cytoskeleton Dynamics: Binds directly to G-actin monomer pools to regulate microfilament assembly, enabling rapid cell migration to sites of tissue injury in fibroblast and endothelial cell models.
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Angiogenesis & Cell Migration: Upregulates vascular endothelial growth factor (VEGF) signaling, supporting the formation of new capillary networks essential for tissue healing and oxygenation.
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Connective Tissue Remodeling: Widely evaluated in orthopedic research models for accelerating matrix synthesis and reducing collagen cross-linking distortion (scarring) in tendons and ligaments.
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Synergistic Healing Models: Frequently paired in dual-peptide research trials with BPC-157 to investigate complementary systemic (TB-500) and localized (BPC-157) tissue regeneration dynamics.
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Aseptic Lyophilized Packaging: Freeze-dried under sterile nitrogen in borosilicate glass vials to ensure maximum structural preservation and long shelf-life prior to reconstitution.
Storage & Handling Guidelines
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Lyophilized Powder: Store at -20°C or -80°C protected from light and moisture for up to 2 years. Short-term storage (under 30 days) at 2–8°C.
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Reconstituted Solution: Once reconstituted with Bacteriostatic Water or sterile saline, store strictly at 2°C – 8°C and use within 28–30 days. Avoid repeated freeze-thaw cycles.
Disclaimer & Research Notice:
This product is sold strictly for laboratory research and analytical purposes only. It is not intended for human consumption, medical diagnosis, therapeutic treatment, or cosmetic applications. All products should be handled by qualified scientific personnel using proper laboratory safety protocols.
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