Trulicity (dulaglutide) Injection

Trulicity (dulaglutide) is a prescription GLP-1 receptor agonist used to improve blood sugar control in adults and children 10 years and older with type 2 diabetes. It is a once-weekly injectable medication that works by helping the body release insulin when blood sugar levels are elevated, slowing stomach emptying, and reducing appetite. Trulicity can be used along with diet and exercise and may also help support modest weight loss in some patients.

Available Strengths

• 0.75 mg/0.5 mL
• 1.5 mg/0.5 mL
• 3 mg/0.5 mL
• 4.5 mg/0.5 mL

Typical Dosing Schedule

• Starting dose: 0.75 mg once weekly
• If additional blood sugar control is needed:
  • Increase to 1.5 mg once weekly after at least 4 weeks
  • Increase to 3 mg once weekly after at least 4 weeks on 1.5 mg
  • Increase to 4.5 mg once weekly after at least 4 weeks on 3 mg

Common Side Effects

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Stomach pain
• Decreased appetite
• Fatigue

These side effects are usually most noticeable when starting treatment or increasing the dose and may improve over time.

Benefits

• Helps lower blood sugar levels in people with type 2 diabetes.
• Supports improved A1C control when combined with diet and exercise.
• Convenient once-weekly injection.
• May help with weight management in some individuals.
• May reduce the risk of certain cardiovascular events in adults with type 2 diabetes and established cardiovascular disease.

Important Safety Information

Trulicity should not be used by individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). It is not recommended during pregnancy unless specifically advised by a healthcare provider. Always use Trulicity exactly as prescribed and follow your healthcare provider’s dosing instructions.