Tesamorelin is a synthetic 44-amino acid polypeptide analog of Growth Hormone-Releasing Hormone (GHRH), modified with a hexenoyl moiety at its N-terminus. Formulated as a high-purity 10mg lyophilized cake, Tesamorelin is a potent and highly selective GHRH receptor agonist studied extensively in neuroendocrine, metabolic, and adipose tissue remodeling research.
It acts on somatotroph cells in the anterior pituitary gland to stimulate synthesis and pulsatile secretion of endogenous growth hormone (GH) without causing significant disruption to baseline glucose homeostasis.
Key Product Specifications
| Specification | Details |
| Product Name | Tesamorelin (Hexenoyl-GHRH) |
| Quantity | 10mg per vial |
| Purity | $\ge 98\%$ (RP-HPLC & Mass Spectrometry verified) |
| Form | Sterile, lyophilized white powder |
| CAS Number | 218949-48-5 |
| Molecular Formula | $\text{C}_{221}\text{H}_{366}\text{N}_{72}\text{O}_{67}\text{S}$ |
| Molecular Weight | $5135.86\text{ g/mol}$ |
| Sequence | Trans-3-hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2 |
Product Highlights & Scientific Context
-
Visceral Adipose Tissue (VAT) Reduction: Primary focus in metabolic research protocols evaluating targeted visceral fat lipolysis, hepatic triglyceride reduction, and liver fat accumulation dynamics.
-
Trans-3-Hexenoyl Modification: Features an N-terminal hexenoyl group that confers increased enzymatic stability and extended plasma half-life compared to native human GHRH (1-44).
-
IGF-1 Cascade Signaling: Upregulates systemic and localized Insulin-like Growth Factor 1 (IGF-1) secretion, supporting research into protein synthesis, lipid oxidation, and body composition regulation.
-
Preserved Endogenous Regulation: Maintains natural pituitary negative feedback regulation via somatostatin release, preserving pulsatile growth hormone secretion patterns.
-
Aseptic Lyophilization: Vacuum-sealed under sterile nitrogen in borosilicate glass vials to ensure long-term secondary structure preservation and batch-to-batch stability.
Storage & Handling Guidelines
-
Lyophilized Powder: Store at -20°C or -80°C protected from light and moisture for up to 2 years. Short-term storage (under 30 days) at 2–8°C.
-
Reconstituted Solution: Once reconstituted with Bacteriostatic Water or sterile saline, store strictly at 2°C – 8°C and use within 28–30 days. Protect from direct heat and light.
Disclaimer & Research Notice:
This product is sold strictly for laboratory research and analytical purposes only. It is not intended for human consumption, medical diagnosis, therapeutic treatment, or cosmetic applications. All products should be handled by qualified scientific personnel using proper laboratory safety protocols.
Reviews
There are no reviews yet.