Sermorelin (GRF 1-29) is a bio-identical synthetic 29-amino acid peptide corresponding to the amino-terminal segment of human Growth Hormone-Releasing Hormone (GHRH). Formulated as a high-purity 10mg lyophilized dose, Sermorelin is a fundamental reagent in neuroendocrine and cellular aging research. It binds specifically to the GHRH receptor on somatotroph cells in the anterior pituitary gland, stimulating natural pulsatile growth hormone secretion while preserving endogenous feedback control mechanisms.
Key Product Specifications
| Specification | Details |
| Product Name | Sermorelin (GRF 1-29 Acetate) |
| Quantity | 10mg per vial |
| Purity | $\ge 98\%$ (RP-HPLC & Mass Spectrometry verified) |
| Form | Sterile, lyophilized white powder |
| CAS Number | 86168-78-7 |
| Molecular Formula | $\text{C}_{149}\text{H}_{246}\text{N}_{44}\text{O}_{42}$ |
| Molecular Weight | $3357.88\text{ g/mol}$ |
| Sequence | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2 |
Product Highlights & Scientific Context
-
Preserved Feedback Homeostasis: Unlike exogenous GH administration, Sermorelin stimulates the pituitary gland within physiological limits, allowing internal somatostatin negative feedback loops to regulate hormone levels naturally.
-
Pulsatile Secretion Profile: Promotes natural episodic pulses of growth hormone release, making it a key experimental standard in studies on somatopause, circadian pituitary rhythms, and body composition regulation.
-
IGF-1 Cascade Activation: Downstream signaling stimulates hepatic secretion of Insulin-like Growth Factor 1 (IGF-1), enabling cellular investigations into tissue repair, protein synthesis, and metabolic rate modulation.
-
Synergistic Secretagogue Protocols: Frequently combined with growth hormone-releasing peptides (GHRPs such as Ipamorelin or GHRP-6) to study dual-pathway somatotroph activation.
-
Vacuum Lyophilized Packaging: Freeze-dried under sterile nitrogen in heavy-duty borosilicate glass vials to prevent degradation and guarantee batch-to-batch consistency.
Storage & Handling Guidelines
-
Lyophilized Powder: Store at -20°C or -80°C protected from light and moisture for up to 2 years. Short-term storage (under 30 days) at 2–8°C.
-
Reconstituted Solution: Once reconstituted with Bacteriostatic Water or sterile saline, store strictly at 2°C – 8°C and use within 28–30 days. Avoid repeated freeze-thaw cycles.
Disclaimer & Research Notice:
This product is sold strictly for laboratory research and analytical purposes only. It is not intended for human consumption, medical diagnosis, therapeutic treatment, or cosmetic applications. All products should be handled by qualified scientific personnel using proper laboratory safety protocols.
Reviews
There are no reviews yet.