NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme found in every living cell, functioning as a primary electron carrier in cellular respiration and metabolic signaling. Formulated as a high-dose 1000mg lyophilized cake, NAD+ is a critical reagent in scientific laboratory research evaluating mitochondrial ATP production, sirtuin ($\text{SIRT}_1\text{–SIRT}_7$) enzymatic activation, poly(ADP-ribose) polymerase (PARP) DNA repair mechanisms, and cellular senescence pathways.
This 1000mg format is specifically designed for high-demand, multi-assay experimental setups and extended longitudinal laboratory protocols.
Key Product Specifications
| Specification | Details |
| Product Name | NAD+ (Nicotinamide Adenine Dinucleotide, oxidized form) |
| Quantity | 1000mg (1g) per vial |
| Purity | $\ge 98\%$ (RP-HPLC & Enzymatic Assay verified) |
| Form | Sterile, lyophilized white-to-off-white powder |
| CAS Number | 53-84-9 |
| Molecular Formula | $\text{C}_{21}\text{H}_{27}\text{N}_{7}\text{O}_{14}\text{P}_2$ |
| Molecular Weight | $663.43\text{ g/mol}$ |
| Primary Biological Role | Coenzyme / Redox cofactor ($\text{NAD}^+/\text{NADH}$) |
Product Highlights & Scientific Context
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Mitochondrial & Metabolic Signaling: Serves as a vital co-substrate for mitochondrial oxidative phosphorylation, enabling efficient electron transport across Complex I and supporting ATP synthesis.
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Sirtuin & Epigenetic Activation: Required cofactor for $\text{NAD}^+$-dependent sirtuin deacetylases, making it a primary focus in gene expression, chromatin remodeling, and longevity research models.
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DNA Damage Repair Protocols: Fuel source for PARP enzymes involved in single-strand and double-strand DNA cleavage repair cascades during cellular oxidative stress assays.
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High-Yield 1000mg Mass: High concentration reduces per-unit costs for high-throughput screening, multi-vial cell culture media supplementation, or long-term animal tissue assays.
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Aseptic Vacuum Packaging: Lyophilized under sterile nitrogen in heavy-duty borosilicate glass vials to prevent hygroscopic degradation and maintain coenzyme activity.
Storage & Handling Guidelines
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Lyophilized Powder: Store at -20°C or -80°C protected from light, heat, and moisture. Extremely hygroscopic; keep vial strictly sealed until reconstitution.
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Reconstituted Solution: Once reconstituted with Bacteriostatic Water or sterile buffer, store strictly at 2°C – 8°C or aliquot and freeze at -20°C. Use reconstituted liquid within 21–30 days. Avoid repeated freeze-thaw cycles.
Disclaimer & Research Notice:
This product is sold strictly for laboratory research and analytical purposes only. It is not intended for human consumption, medical diagnosis, therapeutic treatment, or direct IV infusion. All products should be handled by qualified scientific personnel using proper laboratory safety protocols.
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