Semax is a heptapeptide analog of adrenocorticotropic hormone ($\text{ACTH}_{4-10}$) featuring a unique C-terminal tripeptide extension ($\text{Pro-Gly-Pro}$). Formulated at a high-purity 10mg lyophilized dose, Semax is an extensively studied neuroactive peptide in scientific research settings. It is primarily investigated for its neuroprotective, nootropic, anti-hypoxic, and neurotrophic signaling properties, specifically through the upregulation of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF).
Key Product Specifications
| Specification | Details |
| Product Name | Semax |
| Quantity | 10mg per vial |
| Purity | $\ge 98\%$ (RP-HPLC & Mass Spectrometry verified) |
| Form | Sterile, lyophilized white powder |
| CAS Number | 80714-61-0 |
| Molecular Formula | $\text{C}_{37}\text{H}_{51}\text{N}_9\text{O}_{10}\text{S}$ |
| Molecular Weight | $813.92\text{ g/mol}$ |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
Product Highlights & Scientific Context
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BDNF & NGF Expression: Demonstrates potent capacity to upregulate mRNA levels of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in hippocampal and cortical neuron culture models.
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Pro-Gly-Pro C-Terminal Modification: The addition of the $\text{Pro-Gly-Pro}$ tripeptide sequence provides marked enzymatic resistance against serum peptidases, extending bio-availability compared to native $\text{ACTH}_{4-10}$.
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Dopaminergic & Serotonergic Modulation: Widely evaluated for its ability to modulate central monoamine neurotransmission (dopamine and serotonin turnover) during cognitive performance and stress-adaptation trials.
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Neuroprotection & Anti-Ischemia: Primary focus in cerebral ischemia and hypoxia assays, demonstrating significant reduction of oxidative stress markers and cellular degeneration.
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Aseptic Lyophilized Packaging: Freeze-dried under sterile nitrogen in borosilicate glass vials to ensure optimal structural preservation and long-term storage stability.
Storage & Handling Guidelines
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Lyophilized Powder: Store at -20°C or -80°C protected from light and moisture for up to 2 years. Short-term storage (under 30 days) at 2–8°C.
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Reconstituted Solution: Once reconstituted with Bacteriostatic Water or sterile saline, store strictly at 2°C – 8°C and use within 28–30 days. Protect from direct heat and light.
Disclaimer & Research Notice:
This product is sold strictly for laboratory research and analytical purposes only. It is not intended for human consumption, medical diagnosis, therapeutic treatment, or cosmetic applications. All products should be handled by qualified scientific personnel using proper laboratory safety protocols.
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