Melanotan-2 (MT-II) is a synthetic cyclic lactam analog of the naturally occurring $\alpha$-melanocyte-stimulating hormone ($\alpha$-MSH). Formulated as a high-purity 10mg lyophilized cake, MT-II is widely utilized in laboratory research examining non-selective melanocortin receptor stimulation across the $\text{MC}_1, \text{MC}_3, \text{MC}_4,$ and $\text{MC}_5$ subtypes. It serves as a primary reference compound for investigating melanogenesis, neuro-sexual signaling pathways, central metabolic regulation, and lipid mobilization.
Key Product Specifications
| Specification | Details |
| Product Name | Melanotan-2 / Melanotan II (MT-II) |
| Quantity | 10mg per vial |
| Purity | $\ge 98\%$ (RP-HPLC & Mass Spectrometry verified) |
| Form | Sterile, lyophilized white powder |
| CAS Number | 121062-08-6 |
| Molecular Formula | $\text{C}_{50}\text{H}_{69}\text{N}_{15}\text{O}_{9}$ |
| Molecular Weight | $1024.18\text{ g/mol}$ |
| Sequence | Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 (cyclic lactam) |
Product Highlights & Scientific Context
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Cyclic Lactam Structure: Engineered with a intramolecular lactam bridge between $\text{Asp}^5$ and $\text{Lys}^{10}$ side chains, providing exceptional structural rigidity and enhanced enzymatic resistance compared to linear melanocortin peptides like MT-1.
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Broad Receptor Agonism: Displays potent affinity across multiple melanocortin receptor subtypes ($\text{MC}_{1,3,4,5}$), enabling multi-pathway investigation of pigment synthesis, central thermogenesis, and appetite dynamics.
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Lipolytic & Metabolic Signaling: Evaluated in cellular and preclinical models for its role in stimulating lipolysis via $\text{MC}_4\text{R}$ pathways independent of growth hormone or adrenergic cascades.
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Vacuum Lyophilized Integrity: Sealed in borosilicate glass vials under nitrogen flush to preserve secondary structure and guarantee long-term stability prior to reconstitution.
Storage & Handling Guidelines
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Lyophilized Powder: Store at -20°C or -80°C protected from light and moisture for up to 2 years. Short-term storage (under 30 days) at 2–8°C.
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Reconstituted Solution: Once reconstituted with Bacteriostatic Water or sterile saline, store strictly at 2°C – 8°C and use within 28–30 days. Protect from direct heat and light.
Disclaimer & Research Notice:
This product is sold strictly for laboratory research and analytical purposes only. It is not intended for human consumption, medical diagnosis, therapeutic treatment, or cosmetic applications. All products should be handled by qualified scientific personnel using proper laboratory safety protocols.
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